(*) % of nutrients compared to recommended nutrient intake according to WHO criteria

(**) daily amount not established by WHO

(***) THAI RDI = Thai recommended daily intake for ages of 6 years and up

(****) daily amount not established by THAI RDI

Food advertising no.1544/2565

Food advertising no.1544/2565

Contains protein from milk

Remark

• Food serial no. 74-1-21431-5-0004
• Manufacturer is certified HACCP for enteral nutrition products by SGS (Thailand) Limited
• Registration No. CICOT. HL. 99 B533 012 03 63
• Manufactured by: Thai Otsuka Pharmaceutical Co., Ltd 50, Sethakij 1 Road, Khlong Madua Kra Tum Ban, Samutsakorn, Thailand

Date of manufacture and expiry, see bottom of can

Food advertising no.1544/2565

80 grams of ONCE Dialyze (5 spoons) dissolved in 190 mL water (room temperature, lukewarm or cool water and adjust with water to final volume of 250 mL (approximate 370 Kilocalories).

5 spoon (80 grams) + 190 mL of water = 250 mL (370 Kilocalories)

Storage

• After mixing with water, the prepared solution should be consumed immediately or kept in the refrigerator (2-8°C) with the closed container and should be consumed within 24 hours.
• Close the container tightly after opened and keep in dry place and the product should be consumed within 1 month.

Recommendation for use

• Use under medical supervision for supplement in daily meal of dialysis patients.
• Suspension and precipitation can happen after preparation, the prepared solution can be homogeneous again by shaking or stirring gently.
• Intravenous administration is prohibited.

Medical food must be used under medical supervision.

Food advertising no.1544/2565

Purpose
To study changes in nutritional status and safety in dialysis patients undergoing peritoneal dialysis after receiving ONCE Dialyze
- Primary outcome: nutritional assessment with body weight measurement, Prealbumin and with Modified Subjective Global Assessment
- Secondary outcome: Safety Assessment by gastrointestinal side effects, mineral levels (Electrolyte level)

Methodology
This was a pre-post treatment comparative study (open-label) to determine whether ONCE Dialyze was taken as dietary supplement adding one meal for 15 days in 33 peritoneal dialysis patients at Phramongkutklao Hospital and Chaiyaphum Hospital.

Results
-After receiving ONCE Dialyze for 15 days, patients' nutritional intake (energy, protein, carbs, fat, fiber, potassium, calcium, and magnesium) increased considerably
- Patients who took part in the study showed improved nutritional status. After receiving ONCE Dialyze, the modified SGA score reduced from 24.2 % to 18.2 % (6 % reduction), which was consistent with serum pre-albumin levels and significantlt increased patient's body weight.
- Product safety: There was no evidence of hyperkalemia. High blood calcium and phosphate levels were statistically significant, and none of the subjects in the study experienced any side effects. or have been admitted to a hospital, or have died.

Summary of the study
As ONCE Dialyze is given to people on dialysis who have chronic renal disease as dietary supplement with a typical meal, the patient's nutritional intake including energy, protein, carbohydrate, fat, and fiber was increased, and electrolyte was at proper level. Additionally, it improved the malnutrition condition by the modified SGA score.  Dietary supplement intake for particular disease is an efficient method to increase nutrition for those on dialysis who have chronic kidney disease.

Concentration and volume (1 g = 4.63 kcal, 1 spoon = 16 g)
Concentration (kcal / mL)